Activated Polymorphonuclear Leukocytes Rapidly Synthesize Retinoic Acid Receptor-α
نویسندگان
چکیده
منابع مشابه
Activated Polymorphonuclear Leukocytes Rapidly Synthesize Retinoic Acid Receptor-α
In addition to releasing preformed granular proteins, polymorphonuclear leukocytes (PMNs) synthesize chemokines and other factors under transcriptional control. Here we demonstrate that PMNs express an inducible transcriptional modulator by signal-dependent activation of specialized mechanisms that regulate messenger RNA (mRNA) translation. HL-60 myelocytic cells differentiated to surrogate PMN...
متن کاملHuman Polymorphonuclear Leukocytes by Retinoic Acid and Inhibition of Phorbol Ester-stimulated Chemiluminescence in
Chemiluminescence (CL) is an index of both the generation of and reactions mediated by Cv and 'O2. The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is a potent stim ulator of CL by human polymorphonuclear leukocytes; treat ment with TPA (100 ng/ml) provokes a CL response that peaks within five min and persists for over 30 min. The response is proportional to concentration over th...
متن کاملChemotactic peptide receptor modulation in polymorphonuclear leukocytes
The binding of the chemotactic peptide N-formylnorleucylleucylphenylalanine (FNLLP) to its receptor on rabbit polymorphonuclear leukocytes (PMNs) modulates the number of available peptide receptors. Incubation with FNLLP decreases subsequent binding capacity, a phenomenon that has been termed receptor down regulation. Down regulation of the chemotactic peptide receptor is concentration dependen...
متن کاملRetinoic acid receptor-α in HIV-associated nephropathy.
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden Correspondence: Juan J. Carrero, Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden. E-mail: juan.jesus.ca...
متن کاملPolymorphonuclear Leukocytes
Complete protection of Staphylococcus aureus Wood 46 from gentamicin bactericidal activity was documented for microorganisms located within polymorphonuclear leukocytes. The highest, still ineffective gentamicin concentration tested in the phagocytic assay was 80 times higher than the minimal concentration required to kill uningested organisms. Extracellular gentamicin activity was unaffected b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2004
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20040224